Herpes Zoster and Postherpetic Neuralgia: Past, Present and Future
نویسندگان
چکیده
منابع مشابه
Herpes zoster and postherpetic neuralgia: past, present and future.
OBJECTIVES The history behind the current understanding of the varicella-zoster virus and its relationship to the pain conditions caused by shingles and postherpetic neuralgia are reviewed. The framework for the current conceptualization is Hope-Simpson's latency hypothesis. Data from recent work in virology, neuroanatomy and epidemiology are reviewed, as is work using varicella-zoster virus-in...
متن کاملHerpes zoster and postherpetic neuralgia.
Herpes zoster (HZ; shingles) results from reactivation of varicella-zoster virus that has been dormant in the spinal and cranial sensory ganglia following primary infection with varicella (chickenpox), usually during childhood. In developed countries more than 95% of the adult population are seropositive for varicella-zoster virus and are therefore at risk of developing HZ. Reactivation can occ...
متن کاملHerpes zoster and postherpetic neuralgia.
Pain associated with herpes zoster arise from the virul neuritis of the suffered trigeminal or spinal dorsal ganglion. Prolonged neuritis makes an irreversible nerve injury and continuous pain impulse develops a central sensitization. A post-herpetic neuralgia is thought to be a neuropathic pain due to the irreversible nerve injury and sensitization. It is important to treat herpetic pain compl...
متن کاملVaccination against Herpes Zoster and Postherpetic Neuralgia.
BACKGROUND Herpes zoster (HZ) and postherpetic neuralgia (PHN) cause significant morbidity in older adults. The incidence and severity of HZ and PHN increase with age in association with an age-related decline in varicella-zoster virus (VZV)-specific cell-mediated immunity (VZV-CMI). VZV vaccines can boost VZV-CMI. Therefore, we tested the hypothesis that VZV vaccination would protect older adu...
متن کاملTreating Herpes Zoster and Postherpetic Neuralgia
Michael C. Rowbotham, MD California Pacific Medical Center Research Institute Department of Anesthesia, UCSF School of Medicine San Francisco, Calif., USA Email: [email protected] P ostherpetic neuralgia (PHN) is t e most frequent chronic complication of herpes zoster ( hingles). Herpes zoster (HZ) represents a reactivation of the varicella zo ter vi us (VZV), a ubiquitous, highly neurotropic,...
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ژورنال
عنوان ژورنال: Pain Research and Management
سال: 2009
ISSN: 1203-6765
DOI: 10.1155/2009/380384